Calreticulin, a calcium-binding molecular chaperone, is required

Calreticulin, a calcium-binding molecular chaperone, is required for stress response and sperm fertility in C. elegans


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- 일 시 : 2001년 10월 10일(수) 15:00-16:00


 


- 장 소 : 생명동 104호 세미나실


 


- 연 사 : 안주홍 교수


          (광주 과기원 생명과학과)


 


- Abstract


Calreticulin, a Ca2+-binding protein known to have many cellular functions including regulation of Ca2+ homoeostasis and chaperone activity, is essential for heart and brain development during embryogenesis in mice. Here we report the functional characterization of C. elegans calreticulin (crt-1). A crt-1 null mutant does not result in embryonic lethality but shows temperature-dependent reproduction defects.


In C. elegans CRT-1 is expressed in the intestine, pharynx, body-wall


muscles, head neurons, coelomocytes, and in sperm. crt-1 males exhibit


reduced mating efficiency and defects late in sperm development. dditionally, crt-1 and itr-1 (inositol triphosphate receptor) together are required for normal behavioral rhythms. crt-1 transcript level is elevated under stress conditions suggesting that CRT-1 may be important for stress-induced chaperoning function in C. elegans.


 


- 문의처 : 한진관 교수 (279-2126)