Translation initiation on mRNAs bound by nuclear cap-binding complex

  • 조회 437
  • 작성자 최고관리자
  • 2016-03-16


[2016 Spring Life Sciences & IBB Regular Seminar]

▶Subject: Translation initiation on mRNAs bound by nuclear cap-binding complex

▶Speaker: Prof.Yoon Ki Kim (Division of Life Sciences, Korea University)

▶Date: 4:00PM/Mar. 25(Fri.)/2016

▶Place: Auditorium(1F), Postech Biotech Center

Two major cap-binding components can drive translation initiation in mammals: the nuclear cap-binding complex (CBC), which is a heterodimer of CBP80 and 20, and eukaryotic translation initiation factor 4E (eIF4E). During or right after mRNA export via the nuclear pore complex, mRNAs undergo the first (or pioneer) round of translation, which is mediated by CBC. After CBC-dependent translation, CBC is replaced by eIF4E, which directs steady-state translation. Importantly, nonsense-mediated mRNA decay (NMD), which is the best-characterized mRNA surveillance mechanism and is tightly coupled to translation, is known to occur on CBC-bound mRNAs. However, despite the tight link between CBC-dependent translation and NMD, the underlying molecular mechanism and cellular factors for CBC-dependent translation remain obscure. Our group has recently identified and characterized several factors involved in CBC-dependent translation. These factors include a CBC-dependent translation initiation factor (CTIF), eIF3, and eIF4AIII. How these factors coordinate the CBC-dependent translation will be discussed in the talk. In addition, we has recently observed that CBC-dependent translation is associated with a quality control of newly synthesized polypeptides. The new mode of protein surveillance will be also discussed.

▶Inquiry: Prof. Sung Key Jang (279-2298)
* This seminar will be given in English.
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