Dynamic regulation of axonal mRNA translation during assembly and main…

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  • 2016-03-16


[Jigok Lecture Series]

▶Subject: Dynamic regulation of axonal mRNA translation during assembly and maintenance of the central nervous system

▶Speaker: Prof. Hosung Jung (Department of Anatomy, Yonsei University College of Medicine)

▶Date: 4:30PM/Mar. 17(Thu.)/2016

▶Place: Auditorium(1F), Postech Biotech Center

Local mRNA translation mediates the adaptive responses of axons to extrinsic signals but direct evidence that it occurs in mammalian CNS axons in vivo is scant. We developed an axon-TRAP-RiboTag approach in mouse that allows deep-sequencing analysis of ribosome-bound mRNAs in the retinal ganglion cell axons of the developing and adult retinotectal projection in vivo. The embryonic-to-postnatal axonal translatome comprises an evolving subset of enriched genes with axon-specific roles suggesting distinct steps in axon wiring, such as elongation, pruning and synaptogenesis. Adult axons, remarkably, have a complex translatome with strong links to axon survival, neurotransmission and neurodegenerative disease. Translationally co-regulated mRNA subsets share common upstream regulators and novel sequence elements generated by alternative splicing. Our findings indicate that intricate regulation of compartment-specific mRNA translation supports the formation and maintenance of neural circuits in vivo.

▶Inquiry: Prof. Sang Ki Park(279-2349)
* This seminar will be given in English.
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