By integrating three innovative technologies of single-cell multi-omics, genome editing, and machine learning, we aim to address the following three research questions:
1. What are the genetic and molecular drivers of phenotypic heterogeneity across cells, organs, individuals, and species?
2. How does the collective behavior of a community of cells emerge from the behavior and cellular interactions of individual cells?
3. What are the roles of cellular heterogeneity in the collective behavior of organs or individuals across environments, diseases and species?

본 연구실은 “세포-조직-기관-개체의 계층적 구조에서 가장 하위에 위치한 세포의 유전자 발현 및 표현형의 변이가 상위 생체 시스템의 전체 기능을 어떻게 결정할까?”라는 질문을 가지고 발달, 면역, 종양, 노화 등 다양한 생체 및 질환 시스템의 세포 간 변이와 전체 시스템 기능 간의 인과관계를 연구하고 있다. 이를 위해 단일 세포 다중오믹스 분석, 유전체 편집, 기계 학습 기반 바이오 빅데이터 분석 등 세가지 핵심 기술을 통합하여 세포의 분자적 특성과 기능이 세포간 상호작용을 통하여 조직, 기관, 개체의 전체적인 기능을 결정하는 생물학적 원리를 찾고자 한다.

• ㆍSingle-cell multi-omics
• ㆍBioinformatics
• ㆍMachine learning
• ㆍGenome-wide genetic screening

• ㆍHan et al., (2023) Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement. Nature Aging 3:982-1000
• ㆍKim et al., (2023) Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction. Science Advances 9:eadi8454
• ㆍHa et al., (2022) Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin. Science Advances 8:eabk1239
• ㆍLee et al., (2022) p57Kip2 imposes the reserve stem cell state of gastric chief cells. Cell Stem Cell 29:826-839
• ㆍKwon et al., (2022) Homeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival. Nature Communications 13:1418
• ㆍNahmgoong et al., (2022) Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics. Cell Metabolism 34:458-472
• ㆍLee et al., (2020) Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells. Nature Communications 11:4367
• ㆍHan et al., (2019) Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Cell Stem Cell 25:342-356

• ㆍB.S., POSTECH, Korea (2004)
• ㆍM.S., POSTECH, Korea (2006)
• ㆍPh.D., POSTECH, Korea (2010)

• ㆍ2010-2011: Postdoctoral Fellow, Department of Computer Science, POSTECH
• ㆍ2011-2016: Research Scientist, EMBL-EBI, UK
• ㆍ2016-2020: Assistant Professor, Department of New Biology, DGIST
• ㆍ2020-2021: Associate Professor, Department of New Biology, DGIST
• ㆍ2022-Present: Associate Professor, Department of Life Sciences, POSTECH

• ㆍEditorial Board Member, Molecules and Cells (2021-2023)
• ㆍPromotion Committee Member, The National Project of Bio Big Data (2021-2023)
• ㆍAcademic Committee Member, The Korean Cancer Association (2020-2023)
• ㆍSteering Committee Member, Korean Society for Molecular and Cellular Biology (2021)

• ㆍMicrosoft Research Asia Fellowship, Microsoft Research Asia (2006)
• ㆍTJ Park Bessemer Science Fellowship, POSCO TJ Park Foundation (2009)
• ㆍBest Dissertation Award, Department of Computer Science and Engineering, POSTECH (2010)
• ㆍExcellent Research Award, DGIST (2018)
• ㆍExcellent Academic Research Award, DGIST (2019)