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POSTECH Life Science

KOR

Faculty

Professor
Sang Uk Kim

LIFE SCIENCES

Sang Uk Kim Professor

Structural Biology

ㆍLab
Lab. of Structural Bioinformatics
ㆍDetail research field
Bioinformatics, Precision Medicine
ㆍPhone
+82-54-279-2348
ㆍE-mail
sukim@postech.ac.kr
ㆍHomepage
http://sbi.postech.ac.kr/

Research introduction

We are developing computational biology methods and bioinformatics tools for network medicine and healthcare. Proteins are the major player of cellular function and they carry out their functional role through complex network of protein-protein interactions.
The protein repertoire varies depending on cellular states, tissue type, species, and disease state. However, little is known about how this repertoire changes under different cellular or disease states. To gain a better understanding of these dynamic changes, Kim's lab is developing essential applications for network biology and large-scale high-throughput data integration analysis.
Systemic analysis of protein functional network will provide a framework for understanding how protein compositions respond to changes in human disease states.

Research Area

    Computational Biology and Bioinformatics
  • Structural and functional characterization of membrane proteins
  • Development of prediction methods for protein structure and proteinprotein interaction
  • Systematic & quantitative analyses of molecular evolution and biodiversity
  • Mathematical & statistical approaches to find bio-patterns from sequence and structural information• Protein engineering

Major publications

  • 2023.08. Drug approval prediction based on the discrepancy in gene perturbation effects between cells and humans.(약물 임상승인 예측 인공지능 기술 개발) EBioMedicine. 94:104705
  • 2023.02. An evolution-based machine learning to identify cancer type-specific driver mutations.(유전자 돌연변이 조직 특이적 발암 가능성 예측) Briefings in Bioinformatics. 24(1):bbac593
  • 2022.06. Network-based machine learning approach to predict immunotherapy response in cancer patients. (면역 항암치료제 약물반응을 예측하는 의료 인공지능 개발) Nature Communications. 13(1):3703
  • 2022.02. Evolutionary rewiring of regulatory networks contributes to phenotypic differences between human and mouse orthologous genes.(임상시험 동물모델 정밀제작. 신약 개발과 치료법 찾기 도움) Nucleic Acids Res. 50(4):1849-1863
  • 2020.10. Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients.(암환자의 약물 반응을 예측하는 의료 인공지능 개발) Nature Communications, 11(1):5485
  • 2020.08. Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells.(면역 T 세포 발달경로 규명, 면역세포 치료법개발 실마리) Nature Communications, 11(1):4367
  • 2019.08. Domain-mediated interactions for protein subfamily identification.(암세포를 치료 유전자 발굴 네트워크 분석 방법개발) Scientific Reports. 10(1):264
  • 2019.06. Evolutionary coupling analysis identifies the impact of disease-associated variants at less-conserved sites.(유전자변이 공진화분석을 통한 질병연관성 예측 기술 개발) Nucleic Acids Res. 47(16):e94
  • 2019.05. Epigenetic regulation of mammalian Hedgehog signaling to the stroma determines the molecular subtype of bladder cancer.(암생성 억제인자 분석을 통한 방광암 치료타겟 발굴) Elife 8:e43024
  • 2018.05. Divergence of noncoding regulatory elements explains gene-phenotype differences between human and mouse orthologous genes.(정밀 동물모델 제작에 필요한 질병 유전자표현형) Molecular Biology and Evolution 35(7): 1653-1667

Education

  • B.S., Genetic Engineering, Korea Univ., Seoul, Korea (1992)
  • M.S., Molecular Biology, Korea Univ., Seoul, Korea (1996)
  • Ph.D., Florida State University, Tallahassee, FL, USA (2002)

Career

  • 2002-2005 : Post doctoral fellow, UCLA-DOE Center for Genomics and Proteomics, Los Angeles, CA POSTECH, Pohang, Kyungbuk, Korea
  • 2005.9-2021.2 : Director, Biological Research Information Center (BRIC), Korea
  • 2009.1-2013.12 : KIAS Associate Member, School of computational Science, Korea Institute for Advanced Study, Korea
  • 2017.9-2019.8 : Vice president for admissions and student affairs, POSTECH, Pohang, Kyungbuk, Korea
  • 2017.9-2019.8 : Dean of the School of Undergraduate Studies, POSTECH, Pohang, Kyungbuk, Korea
  • 2019.9-2021.2 : Vice president of Planning, POSTECH, Pohang, Kyungbuk, Korea
  • 2014.3-Presen t: Professor, Department of Life Science, POSTECH, Pohang, Kyungbuk, Korea

Research Image

Sang Uk Kim_Research image

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