본문 바로가기

POSTECH Life Science

KOR

Faculty

Professor
Kwang Soon Kim

LIFE SCIENCES

Kwang Soon Kim Assistant Professor

Immunology

ㆍLab
Lab. of Immune-Microbiota Interaction
ㆍDetail research field
Immune-microbiota interaction, Regulation of anti-commensal antibody responses microbiome-based, targeted therapeutics
ㆍPhone
+82-54-279-8227
ㆍE-mail
kskim27@postech.ac.kr
ㆍHomepage
https://sites.google.com/view/postech-imi-lab/home

Research introduction

The current research in our lab. focuses on the immune-microbiota interaction in health and diseases. Gut microbiota is considered as a hidden organ that influences host physiology even in the extra-intestinal tissues.
Therefore, imbalance of gut microbiota is the key factor that contributes to the rise of chronic immune disorders in modern countries. Based on germ-free mouse facility we had established for the first time in Korea, we are studying intestinal immune system that can shape gut microbiota.
We are also investigating the host-derived, microbial and dietary factors that affect the function of intestinal immune system. Better understanding of immune-microbiota interaction can pave the way for the development of microbiome targeted/based therapeutics against various chronic disorders such as, inflammatory bowel disease (IBD), autoimmune disease, metabolic syndromes and neurological disorders.

Research Area

  • Regulation of intestinal immunity by diet and gut microbiota.
  • Gut fitness of pathogenic commensal microbes and intestinal pathogens
  • Species-specific immune regulation by gut microbes.
  • Pathogenesis of IBD & microbiome targeted/based drugs for IBD
  • Regulation of autoimmunity by gut microbiota

Major publications

  • Hong SW, 0 E, Lee JY, Lee M, Han D, Ko HJ, Sprent J, Surh CD and Kim KS. Food antigens drive spontaneous lgE elevation in the absence of commensal microbiota. Science Advances, 2019. (Recommended by Faculty of 1000)
  • Hong SW, 0 E, Lee JY, Yi J, Cho K, Kim J, Kim D, Surh CD and Kim KS. lnterleukin-2/antibody complex expanding Foxp3+ regulatory T cells exacerbates Th2-mediated allergic airway inflammation. BMB reports, 2019
  • Yi J, Jung JS, Hong SW, Lee JY, Han DH, Kim KS, Sprent J and Surh CD. Unregulated APC activation by T cells breaks self-tolerance. PNAS, 2019.
  • Martin CE, Spasova DS, Frimpong-Boateng K, Kim H, Lee M, Kim KS, Surh CD. lnterleukin-7 homeostasis is maintained by a potent hematopoietic cytokine sink comprised of innate lymphoid cells and T cells, Immunity, 2017.
  • Kim KS, Hong SW, Han D, Yi J, Jung J, Yang BG, Lee JY, Lee M, Surh CD. Dietary Antigens limit mucosa I immunity by inducing regulatory T cells in the small intestine. Science, 2016. (Recommended by Faculty of 1000, Featured paper in 2016 by Society for Mucosal immunology, "2016 BRIC TOP S's" in basic academic part from BRIC)

Education

  • B.S., Yonsei University, Seoul, Korea (1996)
  • Ph.D., POSTECH, Pohang, Korea (2011)

Career

  • 2011-2013 : Postdoctoral Fellow, POSTECH, Pohang, Korea
  • 2013-2017 : Researcher, Institute for Basic Science, Pohang, Korea
  • 2017-2019 : Principal investigator (tenure track), Institute for Basic Science, Pohang, Korea

Research Image

Kwang Soon Kim_Research image

List