LIFE SCIENCES
Seung Yeol Park Associate Professor
Molecular Medicine
- ㆍLab
- Lab. of Membrane and organelle biology
- ㆍDetail research field
- Organelle network, Membrane dynamics
- ㆍPhone
- +82-54-279-2325
- ㆍE-mail
- seungpark@postech.ac.kr
- ㆍHomepage
- http://mbl.postech.ac.kr/
Research introduction
The Golgi complex plays a pivotal role in the secretory pathway. After synthesis in the endoplasmic reticulum (ER), cargoes traverse to the Golgi complex, enabling their transport to final destinations with the appropriate glycosylation. Extensive research has uncovered that organelles in the secretory pathway exert regulatory control over diverse cellular processes, including signal transduction, metabolism, autophagy, and polarity.
The distinct structure of the Golgi complex undergoes changes in patients with specific cancers, immunodeficiency, and neurodegenerative diseases. Consequently, our enduring challenge extends beyond comprehending the mechanisms underlying cargo transport in the secretory pathway to unraveling the molecular dynamics of the membrane under varying conditions.
The distinct structure of the Golgi complex undergoes changes in patients with specific cancers, immunodeficiency, and neurodegenerative diseases. Consequently, our enduring challenge extends beyond comprehending the mechanisms underlying cargo transport in the secretory pathway to unraveling the molecular dynamics of the membrane under varying conditions.
Research Area
- ㆍMembrane dyanmics and trafficking
- ㆍGolgi complex and organelle network
- ㆍGlycosylation in cancer & immunology
- ㆍGolgi signal related to aging process
Major publications
- ㆍTerminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression. Front Oncol. 2023
- ㆍSchizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex. Mol Psychiatry. 2023
- ㆍMON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans. Sci Adv. 2021
- ㆍCombined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex. J Clin Invest. 2021
- ㆍThe late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol. Nat Commun. 2019
- ㆍGAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis. Nature. 2018
- ㆍCoordinated regulation of bidirectional COPI transport at the Golgi by CDC42. Nature. 2015
Education
- ㆍB.S., Ajou University (2006)
- ㆍPh.D., KAIST (2011)
Career
- ㆍ2008-2009 : Visiting scientist, University of Washington & PNRI
- ㆍ2011-2017 : Postdoctoral fellow, Brigham and Women's Hospital & Harvard Medical School
- ㆍ2017-2019 : Instructor, Brigham and Women's Hospital & Harvard Medical School
- ㆍ2019-Present : Assistant Professor, POSTECH
Research Image
