Research areas that we are interested in include cancer and immunology. We have been identifying and investigating novel factors that regulate various immune disorders, including autoimmune diseases, sepsis, and cancers. We are also interested in castration-resistant prostate cancer development.
For our studies, we employ various experimental tools and skills, ranging from molecular and cellular biology to in vivo mouse physiology. The main goal of our study is to provide better insights on therapeutics for cancers and immune disorders.

• ㆍMechanisms underlying tumorigenesis and cancer metastasis.
• ㆍRegulation of immune cell development and immune homeostasis.
• ㆍRegulation of Capicua transcriptional repressor activity.

• ㆍHong et al. (2022) Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis. Cell Reports 38(7):110386
• ㆍKim et al. (2021) Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua. eLife 10:e71769
• ㆍLee (2020) Regulation and function of capicua in mammals. Experimental and Molecular Medicine 52:531-537
• ㆍYoe et al. (2020) Capicua restricts cancer stem cell-like properties in breast cancer cells. Oncogene 39:3489-3506
• ㆍPark et al. (2019) The Capicua/ETS translocation variant 5 axis regulates liver-resident memory CD8+ T-cell development and the pathogenesis of liver injury. Hepatology 70(1):358-371
• ㆍKim et al. (2018) Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4-MMP1 axis. Hepatology 67(6):2287-2301
• ㆍPark et al. (2017) Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5. Nature Communications 8,16037

• ㆍB.S., Seoul National Univ., Seoul, Korea (2001)
• ㆍM.S., Seoul National Univ., Seoul, Korea (2003)
• ㆍPh.D., Seoul National Univ., Seoul, Korea (2006)

• ㆍ2007-2011 : Postdoctoral Fellow, HHMI at Baylor College of Medicine, Houston, USA.
• ㆍ2011-2015 : Assistant professor, Department of Life Sciences, POSTECH
• ㆍ2015-2022 : Associate professor, Department of Life Sciences, POSTECH
• ㆍ2022-Present : Professor, Department of Life Sciences, POSTECH

• ㆍBest thesis award (Korean Society for Molecular and Cellular Biology, 2006)
• ㆍWeintraub graduate student award (Fred Hutchinson Cancer Research Center at Seattle, 2006)
• ㆍBK21 distinguished studentship, President award (Korean Ministry of Science and Technology, 2006)
• ㆍKnowledge creation award (Korean Ministry of Science, ICT and Future Planning, 2013)
• ㆍBlue Ribbon Lecturer (Korean Society for Molecular and Cellular Biology, 2019)
• ㆍMacrogen scientist award (Korean Society for Molecular and Cellular Biology, 2022)
• ㆍMueunjae chair professor (POSTECH, 2022)

• ㆍIdentification of CIC as a tumor suppressor in prostate and liver cancers.
• ㆍIdentification of CIC as a key player in regulation ofTfh cell differentiation and autoimmunity.