Stem Cell and Tissue Regeneration

Based on fundamental biological research on stem cell, the principles of cell fate determination and the process of organismal development will be explored, which lay out a framework for therapeutics development, incorporating cutting-edge, next-generation disease moldeling using organoids and other stem cell-based strategies. Specifically, innovative approaches for disease treatment will be suggested by delving into the mechanisms underlying stem cell differentiation, cellular aging, and tissue regeneration.

Bioinformatics and Computational Biology

Research focused on advancing the fronters of life sciences through the integration of cutting-edge technologies and novel research approaches, employing single-cell multi-omics to investigate biological processes of cells, aiming to elucidate the intricate and heterogeneous networks of cellular interactions. Furthermore, this field leverages the synergistic potential of bioinformatics and machine learning to analyze vast amounts of biological data. This concerted effort is pivotal in identifying etiological factors of diseases and contributing the development of innovative therapeutics interventions.

Organelle Dynamics and Tumor Microenvironment

Research on the dynamics within cells at the molecular level to adapt to various environmental changes. Specifically, it focuses on elucidating how post-translational modifications (PTMs) within cells are regulated during the progression of cancer, neurological diseases, and aging, thereby providing a new perspective in the field of disease treatment.

Synthetic Biolology

Research that explores and applies the fundamental principles of Life Science through an engineering approach that enables the design and construction of living organisms. It is based on the synthesis and manipulation of DNA to create new biological systems and functions, bringing innovation to various fields such as medicine, environment, and energy, thereby contributing to the development of new solutions for a sustainable future.

Gut microbial metabolism and signal transduction

We explore deeply into the microbes present in the gut and the functions and roles of their genes, studying how the metabolic products of these microbes interact with our cellular signaling system to cause various diseases. In particular, we focus on how imbalances in the gut microbial community are caused by factors such as inappropriate lifestyle habits such as a Western-style high-fat diet, antibiocis consumption and inection by pathogens, and how these imbalance affect various human diseases. Our ultimate goal is to develop personalized prevention, diagnosis, and treatment strategies based on an understanding of the human microbiome, by utilizing the latest life science technologies and data analysis methods to clearly interpret the complex interactions between gut microbes and human health.