Molecular Principles of Neural Circuit Development: Synapse Organizers

  • 조회 43
  • 작성자 최고관리자
  • 2017-05-19


[2017 Spring Life Sciences & IBB  Seminar]

▶Subject: Molecular Principles of Neural Circuit Development: Synapse Organizers

▶Speaker: Prof. Jaewon Ko (Department of Brain and Cognitive Sciences, DGIST)
▶Date: 4:30PM/May. 26(Fri.)/2017
▶Place: Auditorium(1F), Postech Biotech Center
The human brain is a sophisticated organ whose functions are encoded by trillions of nerve cells. These nerve cells are connected to each other to form neural circuits responsible for the computational power that directs all human behaviors. To understand the wiring diagram of neural circuits and their fundamental properties, we need to grasp the cellular and molecular mechanisms that underlie the recognition of correct partners and specification of functional synapses, most of which remain elusive.
My talk is based on two hypotheses: first, that multiple trans-synaptic adhesion molecules and their associated proteins (i.e., synapse organizers) are central to synapse formation and function, and second that defective trans-synaptic adhesion signaling manifests in the forms of various brain diseases. I will present and discuss some of our recent studies as exemplaries that relate to key synaptic adhesion signaling pathways that have provided novel molecular frameworks for understanding excitation and inhibition balance at the synapse level, and possibly extrapolated to circuit and systems levels. Our studies also illustrate the importance of an interdisciplinary experimental approach in addressing key neurobiological questions.

▶Inquiry: Prof. Yoontae Lee (279-2354)
* This seminar will be given in English.
Please refrain from taking photos during seminars. *