Mechanisms and physiology of the Golgi complex and intracellular traff…

  • 조회 94
  • 작성자 최고관리자
  • 2018-09-19


▶Subject: Mechanisms and physiology of the Golgi complex and intracellular trafficking

▶Speaker: Seung-Yeol Park, Ph.D (Division of Rheumatology, Immunology and Allergy, Department of Medicine,
                                                                        Brigham and Women’s H ospit al and H ar va r d Medi cal School)

▶Date: 4:00PM/Sept. 3(Mon.)/ 2018

▶Place: Auditorium(1F), Postech Biotech Center

The  Golgi  complex  plays  a  central  role  in  the  sorting  of  cargoes  in  secretory pathway.  While the altered structure of Golgi complex was found in a variety of diseases,  the  mechanisms  of  how  this  organelle  is  regulated  are  less  well understood.  Here we show that polarized Golgi transport regulated by the small GTPase  Cdc42  promotes  cellular  transformation.    Moreover,  CDC42  regulates bidirectional transport within the Golgi complex by targeting the dual functions of  Coat  protein  I  (COPI)  in  cargo  sorting  and  carrier  formation.  CDC42  also directly  imparts  membrane  curvature  to  promote  Golgi  tubule  formation. Further exploring how intracellular transport and tumorigenesis could be linked, we have uncovered a new angle.  We recently discovered that a ciliary protein, intraflagellar  transport  20  (IFT20),  mediates  the  ability  of  Ror2  signaling  to promote tumor invasion.  IFT20 acts in this capacity by promoting Golgi ribbon formation,  which  is  needed  for  the  formation  of  invadopodia,  as  well  as promoting anterograde Golgi transport.  Altogether, these findings advance an understanding of how polarized Golgi transport contributes to tumorigenesis, as the  rapid  growth  and  division  of  tumors  is  predicted  to  require  enhanced secretion.

▶Contact: Department of Life Sciences (Tel. 279-2721)

* This seminar will be given in English.
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