교수진

Charles Surh 교수 Profile

  • 경력
  • 논문
  • 연구분야
| Education |
B.A., University of California at San Diego, USA (1983)
Ph.D., University of California at Davis, USA (1989)

| Career |
1989~1993: Postdoctoral Fellow, Department of Immunology, The Scripps Research Institute
1993~1998: Assistant Professor, Department of Immunology, The Scripps Research Institute
1998~2005: Associate Professor, Department of Immunology, The Scripps Research Institute
2005~2008: Associate Professor with Tenure, Department of Immunology, The Scripps Research Institute, La Jolla, California
2008~2012: Professor, Department of Immunology, The Scripps Research Institute, La Jolla, California
2009~2012: WCU Professor, Division of Integrative Bioscience and Biotechnology, POSTECH
2012~Present: Adjunct Professor, Department of Immunology, The Scripps Research Institute
2012~Present: Adjunct Professor, Division of Development Immunology La Jolla Institute of Allergy and Immunology
2012~Present: Professor, Division of Integrative Bioscience and Biotechnology POSTECH
2012~Present: Director, Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)
1. Kim KS, Hong SW, Han D, Yi J, Jung J, Yang BG, Lee JY, Lee M and Surh CD. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science 2016 Feb 19;351(6275):858-63. doi: 10.1126/science.aac5560. Epub 2016 Jan 28.
2. Martin CE, van Leeuwen EM, Im SJ, Roopenian DC, Sung YC, and Surh CD. IL-7/anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R. Blood 2013 May 30;121(22):4484-92. doi: 10.1182/blood-2012-08-449215. Epub 2013 Apr 22.
3. Surh CD, Sprent J. TGF-β‚ puts the brakes on homeostatic proliferation. Nat Immunol. 2012 Jun 19;13(7):628-30.
4. Sprent J, Surh CD. Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat Immunol. 2011 Jun;131(6):478-84.
5. Martin CE, Kim, DM, Sprent J, Surh CD. Is IL-7 from dendritic cells essential for the homeostasis of CD4+ T cells. Nat Immunol. 2010 Jul;11(7):547-8; author reply 548.
6. Letourneau S, van Leeuwen EMM, Krieg C, Martin C, Pantaleo G, Sprent J, Surh CD, Boyman O. IL-2/anti- IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptorsubunit CD25. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5): 2171-6. Epub 2010 Jan 19.
7. Cho JH, Kim HO, Surh CD, Sprent J. TCR-dependent regulation of lipid rafts controls naive CD8+ T cell homeostasis. Immunity. 2010 Feb 26;32(2):214-26. Epub 2010 Feb 4.
8. Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J. In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med. 2009 Apr 13;206(4):751-60. Epub 2009 Mar 30.
9. Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity 29:848-862 (2008).
| Research Areas |
Development, homeostasis and function of naïve and memory T cells
Modulating T cells populations for treatment of cancer and autoimmune diseases
Regulation of homeostasis between the immune system and the commensal microbiota